1WPL

Crystal structure of the inhibitory form of rat GTP cyclohydrolase I/GFRP complex

Summary for 1WPL

• Entry DOI: 10.2210/pdb1wpl/pdb
• Related: 1is7
• Descriptor: GTP cyclohydrolase I, GTP cyclohydrolase I feedback regulatory protein, ZINC ION, ... (7 entities in total)
• Functional Keywords: enzyme-regulatory protein complex, hydrolase-protein binding complex, hydrolase/protein binding
• Biological source: Rattus norvegicus (Norway rat); More
• Cellular location: Cytoplasm (By similarity): P22288; Nucleus (By similarity): P70552
• Total number of polymer chains: 20
• Total formula weight: 360884.82

Authors

Maita, N.,Hatakeyama, K.,Okada, K.,Hakoshima, T. (deposition date: 2004-09-08, release date: 2004-09-28, Last modification date: 2023-10-25)

• Primary citation: Maita, N.,Hatakeyama, K.,Okada, K.,Hakoshima, T.; Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein; J.Biol.Chem., 279:51534-51540, 2004; PubMed: 15448133; DOI: 10.1074/jbc.M409440200

Experimental method

X-RAY DIFFRACTION (2.8 Å)