1WCI
Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
Summary for 1WCI
Entry DOI | 10.2210/pdb1wci/pdb |
Related | 1DTW 1OLS 1OLU 1OLX 1U5B 1V11 1V16 1V1M 1V1R 1X7W 1X7X 1X7Y 1X7Z 1X80 2BEU 2BEV 2BEW 2BFB 2BFC 2BFD 2BFE 2BFF |
Descriptor | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, CHLORIDE ION, ... (8 entities in total) |
Functional Keywords | oxidoreductase, ketoacid dehydrogenase, branched-chain, multi enzyme complex, acylation, oxidative decarboxylation, maple syrup urine disease, thiamine diphosphate, phosphorylation, conformational switch, reactivity, flavoprotein, maple syru urine disease, mitochondrion, thiamine |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 2 |
Total formula weight | 84373.04 |
Authors | Machius, M.,Wynn, R.M.,Chuang, J.L.,Tomchick, D.R.,Brautigam, C.A.,Chuang, D.T. (deposition date: 2004-11-16, release date: 2006-02-16, Last modification date: 2023-12-13) |
Primary citation | Machius, M.,Wynn, R.M.,Chuang, J.L.,Li, J.,Kluger, R.,Yu, D.,Tomchick, D.R.,Brautigam, C.A.,Chuang, D.T. A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase. Structure, 14:287-, 2006 Cited by PubMed: 16472748DOI: 10.1016/J.STR.2005.10.009 PDB entries with the same primary citation |
Experimental method |
Structure validation
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