1W9N
Isolation and characterization of epilancin 15X, a novel antibiotic from a clinical strain of Staphylococcus epidermidis
Summary for 1W9N
| Entry DOI | 10.2210/pdb1w9n/pdb |
| Related | 1AJ1 1MQX 1MQY 1MQZ 1QOW 1WCO 2DDE 2KTN 2KTO |
| Related PRD ID | PRD_000196 |
| Descriptor | EPILANCIN 15X (1 entity in total) |
| Functional Keywords | antibiotic, type a lantibiotic, lanthionine, antibacterial, thioester |
| Biological source | STAPHYLOCOCCUS EPIDERMIDIS |
| Total number of polymer chains | 1 |
| Total formula weight | 3188.96 |
| Authors | Ekkelenkamp, M.,Hanssen, M.G.M.,Hsu, S.-T.D.,de Jong, A.,Milatovic, D.,Verhoef, J.,van Nuland, N.A.J. (deposition date: 2004-10-14, release date: 2005-04-01, Last modification date: 2024-05-01) |
| Primary citation | Ekkelenkamp, M.B.,Hanssen, M.,Danny Hsu, S.T.,de Jong, A.,Milatovic, D.,Verhoef, J.,van Nuland, N.A. Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis. FEBS Lett., 579:1917-1922, 2005 Cited by PubMed Abstract: The potential application of lantibiotics as food-preserving agents and more recently as antibiotics has strongly increased the interest in these antibacterial peptides. Here, we report the elucidation of the primary and three-dimensional structures of the novel lantibiotic epilancin 15X from Staphylococcus epidermidis using high-resolution nuclear magnetic resonance spectroscopy and tandem mass spectrometry. The molecule contains ten post-translationally modified amino acids, three lanthionine ring structures and a hydroxy-propionyl N-terminal moiety. The primary and tertiary structure and the distribution of positive charges are closely similar to the previously identified lantibiotic epilancin K7, most likely indicative of a common mode of action. PubMed: 15792796DOI: 10.1016/j.febslet.2005.01.083 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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