1MQZ

NMR solution structure of type-B lantibiotics mersacidin bound to lipid II in DPC micelles

Summary for 1MQZ

• Entry DOI: 10.2210/pdb1mqz/pdb
• Related: 1AJ1 1MQX 1MQY 1QOW 1W9N 1WCO 2DDE 2KTN 2KTO
• NMR Information: BMRB: 5580
• Related PRD ID: PRD_000199
• Descriptor: LANTIBIOTIC MERSACIDIN (1 entity in total)
• Functional Keywords: antibiotic, antimicrobial, lantibiotics, bacteriocin, peptidoglycan, methicillin resistance, thioester
• Biological source: BACILLUS SP. HIL-Y85/54728
• Total number of polymer chains: 1
• Total formula weight: 1834.26

Authors

Hsu, S.-T.,Breukink, E.,Bierbaum, G.,Sahl, H.-G.,de Kruijff, B.,Kaptein, R.,van Nuland, N.A.,Bonvin, A.M. (deposition date: 2002-09-17, release date: 2003-03-11, Last modification date: 2018-08-08)

• Primary citation: Hsu, S.-T.,Breukink, E.,Bierbaum, G.,Sahl, H.-G.,De Kruijff, B.,Kaptein, R.,Van Nuland, N.A.,Bonvin, A.M.; NMR Study of Mersacidin and Lipid II Interaction in Dodecylphosphocholine Micelles. Conformational Changes are a Key to Antimicrobial Activity; J.Biol.Chem., 278:13110-, 2003; PubMed: 12562773; DOI: 10.1074/JBC.M211144200

Experimental method

SOLUTION NMR