1W2H

Crystal Structure Of Mycobacterium Tuberculosis Thymidylate Kinase Complexed With Azidothymidine Monophosphate (AZT-MP) (2.0 A Resolution)

1W2H の概要

• エントリーDOI: 10.2210/pdb1w2h/pdb
• 関連するPDBエントリー: 1G3U 1GSI 1GTV 1MRN 1MRS 1N5I 1N5J 1N5K 1N5L 1W2G
• 分子名称: THYMIDYLATE KINASE TMK, 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: transferase, mycobacterium tuberculosis, thymidylate kinase, azt, inhibition mechanism
• 由来する生物種: MYCOBACTERIUM TUBERCULOSIS
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46543.85

構造登録者

Fioravanti, E.,Adam, V.,Munier-Lehmann, H.,Bourgeois, D. (登録日: 2004-07-06, 公開日: 2005-01-12, 最終更新日: 2023-12-13)

• 主引用文献: Fioravanti, E.,Adam, V.,Munier-Lehmann, H.,Bourgeois, D.; The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition.; Biochemistry, 44:130-137, 2005; PubMed: 15628853; DOI: 10.1021/bi0484163

実験手法

X-RAY DIFFRACTION (2 Å)