1W2G

Crystal Structure Of Mycobacterium Tuberculosis Thymidylate Kinase Complexed With Deoxythymidine (dT) (2.1 A Resolution)

1W2G の概要

• エントリーDOI: 10.2210/pdb1w2g/pdb
• 関連するPDBエントリー: 1G3U 1GSI 1GTV 1MRN 1MRS 1N5I 1N5J 1N5K 1N5L 1W2H
• 分子名称: THYMIDYLATE KINASE TMK, ACETATE ION, THYMIDINE, ... (4 entities in total)
• 機能のキーワード: mycobacterium tuberculosis, thymidylate kinase, azt, inhibition mechanism, transferase
• 由来する生物種: MYCOBACTERIUM TUBERCULOSIS
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 45986.64

構造登録者

Fioravanti, E.,Adam, V.,Munier-Lehmann, H.,Bourgeois, D. (登録日: 2004-07-06, 公開日: 2005-01-12, 最終更新日: 2023-12-13)

• 主引用文献: Fioravanti, E.,Adam, V.,Munier-Lehmann, H.,Bourgeois, D.; The Crystal Structure of Mycobacterium Tuberculosis Thymidylate Kinase in Complex with 3'-Azidodeoxythymidine Monophosphate Suggests a Mechanism for Competitive Inhibition; Biochemistry, 44:130-, 2005; PubMed: 15628853; DOI: 10.1021/BI0484163

実験手法

X-RAY DIFFRACTION (2.1 Å)