1W2D

Human Inositol (1,4,5)-trisphosphate 3-kinase complexed with Mn2+/ADP/Ins(1,3,4,5)P4

Summary for 1W2D

• Entry DOI: 10.2210/pdb1w2d/pdb
• Related: 1W2C 1W2F
• Descriptor: INOSITOL-TRISPHOSPHATE 3-KINASE A, ADENOSINE-5'-DIPHOSPHATE, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ... (6 entities in total)
• Functional Keywords: inositol phosphate kinase, adp, ip4, transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 63103.92

Authors

Gonzalez, B.,Schell, M.J.,Irvine, R.F.,Williams, R.L. (deposition date: 2004-07-01, release date: 2004-09-09, Last modification date: 2024-05-08)

• Primary citation: Gonzalez, B.,Schell, M.J.,Letcher, A.J.,Veprintsev, D.B.,Irvine, R.F.,Williams, R.L.; Structure of a Human Inositol 1,4,5-Trisphosphate 3-Kinase; Substrate Binding Reveals Why It is not a Phosphoinositide 3-Kinase; Mol.Cell, 15:689-, 2004; PubMed: 15350214; DOI: 10.1016/J.MOLCEL.2004.08.004

Experimental method

X-RAY DIFFRACTION (1.94 Å)