1VZD
L. CASEI THYMIDYLATE SYNTHASE MUTANT E60Q TERNARY COMPLEX WITH FDUMP AND CB3717
Summary for 1VZD
| Entry DOI | 10.2210/pdb1vzd/pdb |
| Descriptor | THYMIDYLATE SYNTHASE, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total) |
| Functional Keywords | methyltransferase, nucleotide synthase |
| Biological source | Lactobacillus casei |
| Cellular location | Cytoplasm: P00469 |
| Total number of polymer chains | 1 |
| Total formula weight | 37389.10 |
| Authors | Birdsall, D.L.,Finer-Moore, J.,Stroud, R.M. (deposition date: 1996-09-18, release date: 1997-03-12, Last modification date: 2024-02-14) |
| Primary citation | Birdsall, D.L.,Huang, W.,Santi, D.V.,Stroud, R.M.,Finer-Moore, J. The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis. Protein Eng., 11:171-183, 1998 Cited by PubMed: 9613841DOI: 10.1093/protein/11.3.171 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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