Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.

This is a large structure.

Summary for 1VY4

Integrates4QCM 4QCN 4QCO 4QCP
Descriptor16S Ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ... (61 entities in total)
Functional Keywords70s, ribosome, translation, peptydil transfer reaction, proton transfer mechanism, acylated trna
Biological sourceEscherichia coli
Total number of polymer chains112
Total molecular weight4551990.81
Polikanov, Y.S.,Steitz, T.A.,Innis, C.A. (deposition date: 2014-05-13, release date: 2014-08-20, Last modification date: 2019-07-03)
Primary citation
Polikanov, Y.S.,Steitz, T.A.,Innis, C.A.
A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
Nat.Struct.Mol.Biol., 21:787-793, 2014
PubMed: 25132179 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.2871
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone 0.26512 0.7% 12.4% 7.6% 0.50MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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