1UPI

Mycobacterium tuberculosis rmlC epimerase (Rv3465)

Summary for 1UPI

• Entry DOI: 10.2210/pdb1upi/pdb
• Descriptor: DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE (2 entities in total)
• Functional Keywords: epimerase, rhamnose pathway, psi, protein structure initiative, tb structural genomics consortium, tb, tbsgc
• Biological source: MYCOBACTERIUM TUBERCULOSIS
• Total number of polymer chains: 1
• Total formula weight: 24903.82

Authors

Kim, C.-Y.,Naranjo, C.,Waldo, G.S.,Lekin, T.,Segelke, B.W.,Kantardjieff, K.A.,Zemla, A.,Terwilliger, T.,Rupp, B.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2003-10-05, release date: 2003-10-07, Last modification date: 2024-10-16)

Primary citation

Kantardjieff, K.A.,Kim, C.-Y.,Naranjo, C.,Waldo, G.S.,Lekin, T.,Segelke, B.W.,Zemla, A.,Park, M.S.,Terwilliger, T.,Rupp, B.
Mycobacterium Tuberculosis Rmlc Epimerase (Rv3465): A Promising Drug-Target Structure in the Rhamnose Pathway
Acta Crystallogr.,Sect.D, 60:895-, 2004

PubMed Abstract: The Mycobacterium tuberculosis rmlC gene encodes dTDP-4-keto-6-deoxyglucose epimerase, the third enzyme in the M. tuberculosis dTDP-L-rhamnose pathway which is essential for mycobacterial cell-wall synthesis. Because it is structurally unique, highly substrate-specific and does not require a cofactor, RmlC is considered to be the most promising drug target in the pathway, and the M. tuberculosis rmlC gene was selected in the initial round of TB Structural Genomics Consortium targets for structure determination. The 1.7 A native structure determined by the consortium facilities is reported and implications for in silico screening of ligands for structure-guided drug design are discussed.

PubMed: 15103135
DOI: 10.1107/S0907444904005323

Experimental method

X-RAY DIFFRACTION (1.7 Å)