1UPF
STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE, MUTANT C128V BOUND TO THE DRUG 5-FLUOROURACIL
Summary for 1UPF
Entry DOI | 10.2210/pdb1upf/pdb |
Descriptor | URACIL PHOSPHORIBOSYLTRANSFERASE, SULFATE ION, 5-FLUOROURACIL, ... (4 entities in total) |
Functional Keywords | transferase, glycosyltransferase, phosphoribosyltransferase |
Biological source | Toxoplasma gondii |
Total number of polymer chains | 4 |
Total formula weight | 103845.11 |
Authors | Schumacher, M.A.,Carter, D.,Scott, D.,Roos, D.,Ullman, B.,Brennan, R.G. (deposition date: 1998-06-17, release date: 1999-06-22, Last modification date: 2024-02-14) |
Primary citation | Schumacher, M.A.,Carter, D.,Scott, D.M.,Roos, D.S.,Ullman, B.,Brennan, R.G. Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J., 17:3219-3232, 1998 Cited by PubMed: 9628859DOI: 10.1093/emboj/17.12.3219 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report