1UNG

Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.

1UNG の概要

• エントリーDOI: 10.2210/pdb1ung/pdb
• 関連するPDBエントリー: 1H4L 1LFR 1UNH 1UNL
• 分子名称: CELL DIVISION PROTEIN KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1, 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE, ... (4 entities in total)
• 機能のキーワード: cell cycle, complex(kinase-activator), inhibitors, neurodegenerative diseases
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Cytoplasm (By similarity): Q00535; Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side (Probable). Cyclin-dependent kinase 5 activator 1, p25: Nucleus: Q15078
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 113634.96

構造登録者

Mapelli, M.,Crovace, C.,Massimiliano, L.,Musacchio, A. (登録日: 2003-09-10, 公開日: 2004-11-10, 最終更新日: 2023-12-13)

• 主引用文献: Mapelli, M.,Massimilinao, L.,Crovace, C.,Seeliger, M.A.,Tsai, L.-H.,Meijer, L.,Musacchio, A.; Mechanism of Cdk5/P25 Binding by Cdk Inhibitors; J.Med.Chem., 48:671-, 2005; PubMed: 15689152; DOI: 10.1021/JM049323M

実験手法

X-RAY DIFFRACTION (2.3 Å)