Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide Analog ENDKW-[Dap]-S (cyclic)

Summary for 1U91
Related1U8H 1U8I 1U8J 1U8K 1U8L 1U8M 1U8N 1U8O 1U8P 1U8Q 1U92 1U93 1U95 2F5A 2F5B
DescriptorANTIBODY 2F5 (LIGHT CHAIN), ANTIBODY 2F5 (HEAVY CHAIN), GP41 PEPTIDE ANALOG, ... (4 entities in total)
Functional Keywordsfab complex, hiv-1 neutralization, gp41 peptide, immune system
Biological sourceHomo sapiens (human)
Total number of polymer chains3
Total formula weight49183.15
Bryson, S.,Julien, J.-P.,Hynes, R.C.,Pai, E.F. (deposition date: 2004-08-09, release date: 2004-10-05, Last modification date: 2011-07-13)
Primary citationBryson, S.,Hynes, R.C.,Julien, J.-P.,Pai, E.F.
Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications
J.Virol., 83:11862-11875, 2009
PubMed: 19740978
DOI: 110.1128/JVI.01604-09
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-16