1U8C

A novel adaptation of the integrin PSI domain revealed from its crystal structure

1U8C の概要

• エントリーDOI: 10.2210/pdb1u8c/pdb
• 関連するPDBエントリー: 1JV2
• 分子名称: Integrin alpha-V, Integrin beta-3, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: psi domain, integrin, vitronectrin receptor, cell adhesion
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 186847.78

構造登録者

Xiong, J.P.,Stehle, T.,Goodman, S.L.,Arnaout, M.A. (登録日: 2004-08-05, 公開日: 2004-12-28, 最終更新日: 2024-10-16)

主引用文献

Xiong, J.P.,Stehle, T.,Goodman, S.L.,Arnaout, M.A.
A novel adaptation of the integrin PSI domain revealed from its crystal structure.
J.Biol.Chem., 279:40252-40254, 2004

PubMed Abstract: Integrin beta-subunits contain an N-terminal PSI (for plexin-semaphorin-integrin) domain that contributes to integrin activation and harbors the PI(A) alloantigen associated with immune thrombocytopenias and susceptibility to sudden cardiac death. Here we report the crystal structure of PSI in the context of the crystallized alphaVbeta3 ectodomain. The integrin PSI forms a two-stranded antiparallel beta-sheet flanked by two short helices; its long interstrand loop houses Pl(A) and may face the EGF2 domain. The integrin PSI contains four cysteine pairs connected in a 1-4, 2-8, 3-6, 5-7 pattern. An unexpected feature of the structure is that the final, eighth cysteine is located C-terminal to the Ig-like hybrid domain and is thus separated by the hybrid domain from the other seven cysteines of PSI. This architecture may be relevant to the evolution of integrins and should help refine the current models of integrin activation.

PubMed: 15299032
DOI: 10.1074/jbc.C400362200

実験手法

X-RAY DIFFRACTION (3.1 Å)