1U0W

An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases: 18xCHS+resveratrol Structure

Summary for 1U0W

Entry DOI	10.2210/pdb1u0w/pdb
Related	1BI5 1U0U 1U0V
Descriptor	Chalcone synthase 2, RESVERATROL (3 entities in total)
Functional Keywords	type iii polyketide synthase, pks, condensing enzyme, thiolase fold, alpha-beta-alpha-beta-alpha fold, aldol switch, catalytic triad, engineered resveratrol synthase, rs, sts, chs, chalcone synthase, stilbene synthase, transferase
Biological source	Medicago sativa
Total number of polymer chains	4
Total formula weight	172410.27
Authors	Austin, M.B.,Bowman, M.E.,Ferrer, J.-L.,Schroder, J.,Noel, J.P. (deposition date: 2004-07-14, release date: 2004-10-12, Last modification date: 2023-08-23)
Primary citation	Austin, M.B.,Bowman, M.E.,Ferrer, J.-L.,Schroder, J.,Noel, J.P. An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases Chem.Biol., 11:1179-1194, 2004 Cited by PubMed: 15380179 DOI: 10.1016/j.chembiol.2004.05.024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation