1U0W
An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases: 18xCHS+resveratrol Structure
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Chalcone synthase 2 | polymer | 393 | 42874.3 | 4 | UniProt (P30074) Pfam (PF00195) Pfam (PF02797) In PDB | Medicago sativa | Naringenin-chalcone synthase 2 |
2 | A, B, C, D | RESVERATROL | non-polymer | 228.2 | 4 | Chemie (STL) | |||
3 | water | water | 18.0 | 1190 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 389 (UniProt: P30074)
PDB | External Database | Details |
---|---|---|
Gly -3 | - | cloning artifact |
Ser -2 | - | cloning artifact |
His -1 | - | cloning artifact |
Gly 0 | - | cloning artifact |
Ala 96 | Asp 96 | engineered mutation |
Leu 98 | Val 98 | engineered mutation |
Ala 99 | Val 99 | engineered mutation |
Met 100 | Val 100 | engineered mutation |
Ser 131 | Thr 131 | engineered mutation |
Thr 133 | Ser 133 | engineered mutation |
Thr 134 | Gly 134 | engineered mutation |
Pro 135 | Val 135 | engineered mutation |
Leu 137 | Met 137 | engineered mutation |
Val 157 | Tyr 157 | engineered mutation |
Gly 158 | Met 158 | engineered mutation |
Val 159 | Met 159 | engineered mutation |
Phe 160 | Tyr 160 | engineered mutation |
His 162 | Gln 162 | engineered mutation |
Lys 268 | Leu 268 | engineered mutation |
Gly 269 | Lys 269 | engineered mutation |
Ala 270 | Asp 270 | engineered mutation |
Asp 273 | Gly 273 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 171497.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 913.0 | |
All* | Total formula weight | 172410.3 |