1U0M
Crystal Structure of 1,3,6,8-Tetrahydroxynaphthalene Synthase (THNS) from Streptomyces coelicolor A3(2): a Bacterial Type III Polyketide Synthase (PKS) Provides Insights into Enzymatic Control of Reactive Polyketide Intermediates
Summary for 1U0M
| Entry DOI | 10.2210/pdb1u0m/pdb |
| Descriptor | putative polyketide synthase, POLYETHYLENE GLYCOL (N=34), GLYCEROL, ... (4 entities in total) |
| Functional Keywords | type iii polyketide synthase, pks, bacterial, thiolase fold, alpha-beta-alpha-beta-alpha fold, catalytic triad, chs-like, thns, tetrahydroxynaphthalene synthase, chalcone/stilbene synthase superfamily, malonyl-coa, biosynthetic protein |
| Biological source | Streptomyces coelicolor |
| Total number of polymer chains | 2 |
| Total formula weight | 86582.49 |
| Authors | Austin, M.B.,Izumikawa, M.,Bowman, M.E.,Udwary, D.W.,Ferrer, J.L.,Moore, B.S.,Noel, J.P. (deposition date: 2004-07-13, release date: 2004-09-14, Last modification date: 2024-02-14) |
| Primary citation | Austin, M.B.,Izumikawa, M.,Bowman, M.E.,Udwary, D.W.,Ferrer, J.L.,Moore, B.S.,Noel, J.P. Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates J.Biol.Chem., 279:45162-45174, 2004 Cited by PubMed: 15265863DOI: 10.1074/jbc.M406567200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
Download full validation report
