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1TVO

The structure of ERK2 in complex with a small molecule inhibitor

Summary for 1TVO
Entry DOI10.2210/pdb1tvo/pdb
DescriptorMitogen-activated protein kinase 1, 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE (3 entities in total)
Functional Keywordskinase, protein-inhibitor complex, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, spindle : P28482
Total number of polymer chains1
Total formula weight42558.78
Authors
Kinoshita, T. (deposition date: 2004-06-30, release date: 2005-09-13, Last modification date: 2024-03-13)
Primary citationOhori, M.,Kinoshita, T.,Okubo, M.,Sato, K.,Yamazaki, A.,Arakawa, H.,Nishimura, S.,Inamura, N.,Nakajima, H.,Neya, M.,Miyake, H.,Fujii, T.
Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex
Biochem.Biophys.Res.Commun., 336:357-363, 2005
Cited by
PubMed: 16139248
DOI: 10.1016/j.bbrc.2005.08.082
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

건을2024-03-27부터공개중

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