1TVH
Crystal structure of Modified Melanoma Antigen gp100(209-T2M) Bound to Human Class I MHC HLA-A2
Summary for 1TVH
Entry DOI | 10.2210/pdb1tvh/pdb |
Related | 1DUZ 1QR1 1TVB |
Descriptor | HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, epitope of Melanocyte protein Pmel 17, ... (5 entities in total) |
Functional Keywords | melanoma; x-ray; modified gp100 peptide; gp100(209-t2m) peptide; mhc; hla-a2, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01892 Secreted: P61769 Endoplasmic reticulum membrane; Single-pass type I membrane protein. M-alpha: Secreted: P40967 |
Total number of polymer chains | 6 |
Total formula weight | 92116.18 |
Authors | Borbulevych, O.Y.,Baker, B.M. (deposition date: 2004-06-29, release date: 2005-04-19, Last modification date: 2023-08-23) |
Primary citation | Borbulevych, O.Y.,Baxter, T.K.,Yu, Z.,Restifo, N.P.,Baker, B.M. Increased Immunogenicity of an Anchor-Modified Tumor-Associated Antigen Is Due to the Enhanced Stability of the Peptide/MHC Complex: Implications for Vaccine Design J.Immunol., 174:4812-4820, 2005 Cited by PubMed: 15814707PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.802 Å) |
Structure validation
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