1TVH
Crystal structure of Modified Melanoma Antigen gp100(209-T2M) Bound to Human Class I MHC HLA-A2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 275 | 31854.2 | 2 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (human) | |
| 2 | B, E (B, E) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 2 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C, F (C, F) | epitope of Melanocyte protein Pmel 17 | polymer | 9 | 1035.2 | 2 | UniProt (P40967) | ||
| 4 | AA, BA, CA, DA, EA... (D, E, A, B, C) | GLYCEROL | non-polymer | 92.1 | 28 | Chemie (GOL) | |||
| 5 | IA, JA, KA, LA, MA... (A, B, C, D, E...) | water | water | 18.0 | 726 | Chemie (HOH) |
Sequence modifications
B, E: 1 - 99 (UniProt: P61769)
C, F: 1 - 9 (UniProt: P40967)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 2 | Thr 210 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 89537.5 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 2578.6 | |
| All* | Total formula weight | 92116.2 |
