1TVH
Crystal structure of Modified Melanoma Antigen gp100(209-T2M) Bound to Human Class I MHC HLA-A2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0002477 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class Ib |
| B | 0002502 | biological_process | peptide antigen assembly with MHC class I protein complex |
| B | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
| B | 0002715 | biological_process | regulation of natural killer cell mediated immunity |
| B | 0002726 | biological_process | positive regulation of T cell cytokine production |
| B | 0005198 | molecular_function | structural molecule activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005925 | cellular_component | focal adhesion |
| B | 0006879 | biological_process | intracellular iron ion homeostasis |
| B | 0006955 | biological_process | immune response |
| B | 0007608 | biological_process | sensory perception of smell |
| B | 0007611 | biological_process | learning or memory |
| B | 0009897 | cellular_component | external side of plasma membrane |
| B | 0009986 | cellular_component | cell surface |
| B | 0010038 | biological_process | response to metal ion |
| B | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| B | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| B | 0023026 | molecular_function | MHC class II protein complex binding |
| B | 0030670 | cellular_component | phagocytic vesicle membrane |
| B | 0031901 | cellular_component | early endosome membrane |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0031905 | cellular_component | early endosome lumen |
| B | 0033572 | biological_process | transferrin transport |
| B | 0034756 | biological_process | regulation of iron ion transport |
| B | 0034757 | biological_process | negative regulation of iron ion transport |
| B | 0035580 | cellular_component | specific granule lumen |
| B | 0042605 | molecular_function | peptide antigen binding |
| B | 0042612 | cellular_component | MHC class I protein complex |
| B | 0042613 | cellular_component | MHC class II protein complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0042824 | cellular_component | MHC class I peptide loading complex |
| B | 0048260 | biological_process | positive regulation of receptor-mediated endocytosis |
| B | 0048261 | biological_process | negative regulation of receptor-mediated endocytosis |
| B | 0050680 | biological_process | negative regulation of epithelial cell proliferation |
| B | 0050768 | biological_process | negative regulation of neurogenesis |
| B | 0050778 | biological_process | positive regulation of immune response |
| B | 0050870 | biological_process | positive regulation of T cell activation |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 0055038 | cellular_component | recycling endosome membrane |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071281 | biological_process | cellular response to iron ion |
| B | 0071316 | biological_process | cellular response to nicotine |
| B | 1904724 | cellular_component | tertiary granule lumen |
| B | 1990000 | biological_process | amyloid fibril formation |
| B | 1990712 | cellular_component | HFE-transferrin receptor complex |
| B | 2000774 | biological_process | positive regulation of cellular senescence |
| B | 2000978 | biological_process | negative regulation of forebrain neuron differentiation |
| E | 0000139 | cellular_component | Golgi membrane |
| E | 0002477 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class Ib |
| E | 0002502 | biological_process | peptide antigen assembly with MHC class I protein complex |
| E | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
| E | 0002715 | biological_process | regulation of natural killer cell mediated immunity |
| E | 0002726 | biological_process | positive regulation of T cell cytokine production |
| E | 0005198 | molecular_function | structural molecule activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005765 | cellular_component | lysosomal membrane |
| E | 0005783 | cellular_component | endoplasmic reticulum |
| E | 0005788 | cellular_component | endoplasmic reticulum lumen |
| E | 0005794 | cellular_component | Golgi apparatus |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0005925 | cellular_component | focal adhesion |
| E | 0006879 | biological_process | intracellular iron ion homeostasis |
| E | 0006955 | biological_process | immune response |
| E | 0007608 | biological_process | sensory perception of smell |
| E | 0007611 | biological_process | learning or memory |
| E | 0009897 | cellular_component | external side of plasma membrane |
| E | 0009986 | cellular_component | cell surface |
| E | 0010038 | biological_process | response to metal ion |
| E | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| E | 0016020 | cellular_component | membrane |
| E | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| E | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| E | 0023026 | molecular_function | MHC class II protein complex binding |
| E | 0030670 | cellular_component | phagocytic vesicle membrane |
| E | 0031901 | cellular_component | early endosome membrane |
| E | 0031902 | cellular_component | late endosome membrane |
| E | 0031905 | cellular_component | early endosome lumen |
| E | 0033572 | biological_process | transferrin transport |
| E | 0034756 | biological_process | regulation of iron ion transport |
| E | 0034757 | biological_process | negative regulation of iron ion transport |
| E | 0035580 | cellular_component | specific granule lumen |
| E | 0042605 | molecular_function | peptide antigen binding |
| E | 0042612 | cellular_component | MHC class I protein complex |
| E | 0042613 | cellular_component | MHC class II protein complex |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0042803 | molecular_function | protein homodimerization activity |
| E | 0042824 | cellular_component | MHC class I peptide loading complex |
| E | 0048260 | biological_process | positive regulation of receptor-mediated endocytosis |
| E | 0048261 | biological_process | negative regulation of receptor-mediated endocytosis |
| E | 0050680 | biological_process | negative regulation of epithelial cell proliferation |
| E | 0050768 | biological_process | negative regulation of neurogenesis |
| E | 0050778 | biological_process | positive regulation of immune response |
| E | 0050870 | biological_process | positive regulation of T cell activation |
| E | 0051289 | biological_process | protein homotetramerization |
| E | 0055038 | cellular_component | recycling endosome membrane |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 0071281 | biological_process | cellular response to iron ion |
| E | 0071316 | biological_process | cellular response to nicotine |
| E | 1904724 | cellular_component | tertiary granule lumen |
| E | 1990000 | biological_process | amyloid fibril formation |
| E | 1990712 | cellular_component | HFE-transferrin receptor complex |
| E | 2000774 | biological_process | positive regulation of cellular senescence |
| E | 2000978 | biological_process | negative regulation of forebrain neuron differentiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 1001 |
| Chain | Residue |
| A | THR80 |
| A | TYR84 |
| A | LYS146 |
| B | PRO14 |
| C | VAL9 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1002 |
| Chain | Residue |
| A | HOH1190 |
| A | HIS145 |
| A | GLU148 |
| A | LEU272 |
| A | ARG273 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1003 |
| Chain | Residue |
| B | PRO5 |
| B | LYS6 |
| B | ILE7 |
| B | HOH1073 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1004 |
| Chain | Residue |
| A | TYR27 |
| A | GLN32 |
| A | HOH1046 |
| A | HOH1156 |
| A | HOH1165 |
| A | HOH1217 |
| A | HOH1226 |
| A | HOH1260 |
| B | SER52 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 1005 |
| Chain | Residue |
| D | TYR84 |
| D | HIS191 |
| D | HIS192 |
| D | ALA193 |
| D | HOH1034 |
| D | HOH1090 |
| D | HOH1137 |
| D | HOH1200 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL E 1006 |
| Chain | Residue |
| E | PRO5 |
| E | LYS6 |
| E | ILE7 |
| E | LYS91 |
| E | VAL93 |
| E | HOH1125 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D 1007 |
| Chain | Residue |
| D | ASP30 |
| D | THR31 |
| D | ARG181 |
| D | TYR209 |
| D | GLY239 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL D 1008 |
| Chain | Residue |
| D | ARG6 |
| D | PHE8 |
| D | TYR27 |
| D | ASP29 |
| D | ASP30 |
| D | GOL1009 |
| D | HOH1266 |
| E | TYR63 |
| E | HOH1113 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL D 1009 |
| Chain | Residue |
| D | THR233 |
| D | PHE241 |
| D | GOL1008 |
| E | TYR26 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 1010 |
| Chain | Residue |
| A | ARG75 |
| B | GLU16 |
| B | ASN17 |
| B | HOH1043 |
| B | HOH1129 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1011 |
| Chain | Residue |
| A | GLU212 |
| A | ILE213 |
| A | THR214 |
| A | GLN262 |
| A | HIS263 |
| A | GLU264 |
| A | HOH1141 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 1012 |
| Chain | Residue |
| A | ASP61 |
| A | ARG65 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 1013 |
| Chain | Residue |
| D | GLU58 |
| D | TYR59 |
| D | GLY62 |
| D | GLU63 |
| D | LYS66 |
| D | HOH1086 |
| D | HOH1270 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1014 |
| Chain | Residue |
| A | TYR84 |
| A | HIS191 |
| A | HIS192 |
| A | ALA193 |
| A | HOH1030 |
| A | HOH1072 |
| A | HOH1096 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1015 |
| Chain | Residue |
| A | GLU232 |
| B | GLY29 |
| B | SER57 |
| B | SER61 |
| B | PHE62 |
| B | HOH1085 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL E 1016 |
| Chain | Residue |
| E | ARG3 |
| E | THR4 |
| E | HOH1080 |
| E | HOH1119 |
| E | HOH1127 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL D 1017 |
| Chain | Residue |
| D | SER42 |
| D | GLU46 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 1018 |
| Chain | Residue |
| A | PRO50 |
| A | THR178 |
| site_id | CC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL D 1019 |
| Chain | Residue |
| D | ARG234 |
| D | GLN242 |
| D | GOL1024 |
| D | HOH1165 |
| D | HOH1284 |
| E | SER11 |
| E | HIS13 |
| E | PRO14 |
| D | LEU206 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 1020 |
| Chain | Residue |
| A | PRO269 |
| A | HOH1182 |
| D | ARG131 |
| D | GLU154 |
| D | ARG157 |
| D | HOH1195 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1021 |
| Chain | Residue |
| A | TYR85 |
| A | GLN87 |
| A | TYR118 |
| A | ASP119 |
| A | LYS121 |
| A | HOH1129 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL D 1022 |
| Chain | Residue |
| D | ARG44 |
| D | ASP61 |
| D | THR64 |
| D | HOH1258 |
| site_id | CC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 1023 |
| Chain | Residue |
| B | THR71 |
| B | THR73 |
| site_id | CC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 1024 |
| Chain | Residue |
| D | TYR84 |
| D | LYS146 |
| D | HIS188 |
| D | THR190 |
| D | TRP204 |
| D | GOL1019 |
| E | MET99 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 1025 |
| Chain | Residue |
| D | GLY237 |
| D | HOH1088 |
| D | HOH1275 |
| E | LEU65 |
| E | TYR67 |
| E | HOH1032 |
| site_id | CC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL E 1026 |
| Chain | Residue |
| E | LEU87 |
| E | SER88 |
| E | HOH1107 |
| site_id | CC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1027 |
| Chain | Residue |
| A | ARG6 |
| A | PHE8 |
| A | ASP29 |
| A | ASP30 |
| A | HOH1053 |
| A | HOH1186 |
| A | HOH1198 |
| A | HOH1202 |
| B | TYR63 |
| site_id | DC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL D 1028 |
| Chain | Residue |
| D | THR228 |
| D | GLU229 |
| D | LEU230 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH |
| Chain | Residue | Details |
| B | TYR78-HIS84 | |
| A | TYR257-HIS263 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 172 |
| Details | Domain: {"description":"Ig-like C1-type","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 178 |
| Details | Region: {"description":"Alpha-1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 182 |
| Details | Region: {"description":"Alpha-2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 182 |
| Details | Region: {"description":"Alpha-3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21943705","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21543847","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Sulfotyrosine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 176 |
| Details | Domain: {"description":"Ig-like C1-type"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 12 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 16 |
| Details | Region: {"description":"Antigenic peptide; presented by A*02:01","evidences":[{"source":"PubMed","id":"7706734","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
