1TVH

Crystal structure of Modified Melanoma Antigen gp100(209-T2M) Bound to Human Class I MHC HLA-A2

1TVH の概要

• エントリーDOI: 10.2210/pdb1tvh/pdb
• 関連するPDBエントリー: 1DUZ 1QR1 1TVB
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, epitope of Melanocyte protein Pmel 17, ... (5 entities in total)
• 機能のキーワード: melanoma; x-ray; modified gp100 peptide; gp100(209-t2m) peptide; mhc; hla-a2, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769; Endoplasmic reticulum membrane; Single-pass type I membrane protein. M-alpha: Secreted: P40967
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 92116.18

構造登録者

Borbulevych, O.Y.,Baker, B.M. (登録日: 2004-06-29, 公開日: 2005-04-19, 最終更新日: 2023-08-23)

• 主引用文献: Borbulevych, O.Y.,Baxter, T.K.,Yu, Z.,Restifo, N.P.,Baker, B.M.; Increased Immunogenicity of an Anchor-Modified Tumor-Associated Antigen Is Due to the Enhanced Stability of the Peptide/MHC Complex: Implications for Vaccine Design; J.Immunol., 174:4812-4820, 2005; PubMed: 15814707

実験手法

X-RAY DIFFRACTION (1.802 Å)