1TPX

Ovine recombinant PrP(114-234), ARQ variant in complex with the Fab of the VRQ14 antibody

Summary for 1TPX

Entry DOI	10.2210/pdb1tpx/pdb
Descriptor	major prion protein, the VRQ14 Fab, ... (4 entities in total)
Functional Keywords	prion, antibody, unknown function
Biological source	Ovis aries (sheep) More
Total number of polymer chains	3
Total formula weight	60831.69
Authors	Eghiaian, F.,Grosclaude, J.,Lesceu, S.,Debey, P.,Doublet, B.,Treguer, E.,Rezaei, H.,Knossow, M. (deposition date: 2004-06-16, release date: 2004-07-06, Last modification date: 2011-07-13)
Primary citation	Eghiaian, F.,Grosclaude, J.,Lesceu, S.,Debey, P.,Doublet, B.,Treguer, E.,Rezaei, H.,Knossow, M. Insight into the PrPC -> PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants. Proc.Natl.Acad.Sci.USA, 101:10254-10259, 2004 Cited by PubMed: 15240887 DOI: 10.1073/pnas.0400014101 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.56 Å)

Structure validation