1TF6

CO-CRYSTAL STRUCTURE OF XENOPUS TFIIIA ZINC FINGER DOMAIN BOUND TO THE 5S RIBOSOMAL RNA GENE INTERNAL CONTROL REGION

1TF6 の概要

• エントリーDOI: 10.2210/pdb1tf6/pdb
• 分子名称: DNA (5'-D(*AP*CP*GP*GP*GP*CP*CP*TP*GP*GP*TP*TP*AP*GP*TP*AP*C P*CP*TP*GP*GP*AP* TP*GP*GP*GP*AP*GP*AP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*TP*CP*TP*CP*CP*CP*AP*TP*CP*CP*AP*GP*GP*T P*AP*CP*TP*AP*AP* CP*CP*AP*GP*GP*CP*CP*CP*G)-3'), PROTEIN (TRANSCRIPTION FACTOR IIIA), ... (4 entities in total)
• 機能のキーワード: complex (transcription regulation-dna), rna polymerase iii, transcription initiation, zinc finger protein, transcription-dna complex, transcription/dna
• 由来する生物種: Xenopus laevis (African clawed frog)
• 細胞内の位置: Nucleus: P03001
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 83174.40

構造登録者

Nolte, R.T.,Conlin, R.M.,Harrison, S.C.,Brown, R.S. (登録日: 1998-03-02, 公開日: 1998-07-10, 最終更新日: 2024-02-14)

主引用文献

Nolte, R.T.,Conlin, R.M.,Harrison, S.C.,Brown, R.S.
Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex.
Proc.Natl.Acad.Sci.USA, 95:2938-2943, 1998

PubMed Abstract: The crystal structure of the six NH2-terminal zinc fingers of Xenopus laevis transcription factor IIIA (TFIIIA) bound with 31 bp of the 5S rRNA gene promoter has been determined at 3.1 A resolution. Individual zinc fingers are positioned differently in the major groove and across the minor groove of DNA to span the entire length of the duplex. These results show how TFIIIA can recognize several separated DNA sequences by using fewer fingers than necessary for continuous winding in the major groove.

PubMed: 9501194
DOI: 10.1073/pnas.95.6.2938

実験手法

X-RAY DIFFRACTION (3.1 Å)