1TC2
TERNARY SUBSTRATE COMPLEX OF THE HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE FROM TRYPANOSOMA CRUZI
Summary for 1TC2
Entry DOI | 10.2210/pdb1tc2/pdb |
Descriptor | PROTEIN (HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE), MAGNESIUM ION, 7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE, ... (6 entities in total) |
Functional Keywords | transferase, glycosyltransferase, phosphoribosyltransferase, nucleotide metabolism, purine salvage, ternary complex, near transition state |
Biological source | Trypanosoma cruzi |
Cellular location | Cytoplasm : Q27796 |
Total number of polymer chains | 2 |
Total formula weight | 52371.02 |
Authors | Focia, P.J.,Craig III, S.P.,Eakin, A.E. (deposition date: 1998-11-04, release date: 2000-03-08, Last modification date: 2023-08-23) |
Primary citation | Focia, P.J.,Craig III, S.P.,Eakin, A.E. Approaching the transition state in the crystal structure of a phosphoribosyltransferase. Biochemistry, 37:17120-17127, 1998 Cited by PubMed: 9860824DOI: 10.1021/bi9821465 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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