1T84

Solution structure of the Wiskott-Aldrich Syndrome Protein (WASP) autoinhibited core domain complexed with (S)-wiskostatin, a small molecule inhibitor

Summary for 1T84

• Entry DOI: 10.2210/pdb1t84/pdb
• Related: 1CEE 1EJ5
• Descriptor: Wiskott-Aldrich syndrome protein, (2S)-1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL (2 entities in total)
• Functional Keywords: alpha helix, beta-hairpin turn, signaling protein
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton: P42768
• Total number of polymer chains: 1
• Total formula weight: 12029.74

Authors

Peterson, J.R.,Bickford, L.C.,Morgan, D.,Kim, A.S.,Ouerfelli, O.,Kirschner, M.W.,Rosen, M.K. (deposition date: 2004-05-11, release date: 2004-07-13, Last modification date: 2022-03-02)

• Primary citation: Peterson, J.R.,Bickford, L.C.,Morgan, D.,Kim, A.S.,Ouerfelli, O.,Kirschner, M.W.,Rosen, M.K.; Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.; Nat.Struct.Mol.Biol., 11:747-755, 2004; PubMed: 15235593; DOI: 10.1038/nsmb796

Experimental method

SOLUTION NMR