1T84
Solution structure of the Wiskott-Aldrich Syndrome Protein (WASP) autoinhibited core domain complexed with (S)-wiskostatin, a small molecule inhibitor
Summary for 1T84
Entry DOI | 10.2210/pdb1t84/pdb |
Related | 1CEE 1EJ5 |
Descriptor | Wiskott-Aldrich syndrome protein, (2S)-1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL (2 entities in total) |
Functional Keywords | alpha helix, beta-hairpin turn, signaling protein |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton: P42768 |
Total number of polymer chains | 1 |
Total formula weight | 12029.74 |
Authors | Peterson, J.R.,Bickford, L.C.,Morgan, D.,Kim, A.S.,Ouerfelli, O.,Kirschner, M.W.,Rosen, M.K. (deposition date: 2004-05-11, release date: 2004-07-13, Last modification date: 2024-05-22) |
Primary citation | Peterson, J.R.,Bickford, L.C.,Morgan, D.,Kim, A.S.,Ouerfelli, O.,Kirschner, M.W.,Rosen, M.K. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat.Struct.Mol.Biol., 11:747-755, 2004 Cited by PubMed: 15235593DOI: 10.1038/nsmb796 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report