1T84
Solution structure of the Wiskott-Aldrich Syndrome Protein (WASP) autoinhibited core domain complexed with (S)-wiskostatin, a small molecule inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0007015 | biological_process | actin filament organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE WSK A 108 |
| Chain | Residue |
| A | VAL6 |
| A | GLY57 |
| A | GLY58 |
| A | LEU59 |
| A | VAL9 |
| A | GLY10 |
| A | TRP11 |
| A | PHE17 |
| A | SER46 |
| A | TYR50 |
| A | ILE53 |
| A | GLU54 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by FYN and HCK => ECO:0000269|PubMed:12235133, ECO:0000269|PubMed:14707117, ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | TYR50 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:12769847, ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:12769847, ECO:0007744|PubMed:18088087 |
| Chain | Residue | Details |
