1T84
Solution structure of the Wiskott-Aldrich Syndrome Protein (WASP) autoinhibited core domain complexed with (S)-wiskostatin, a small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Wiskott-Aldrich syndrome protein | polymer | 107 | 11603.6 | 1 | UniProt (P42768) Pfam (PF00786) In PDB | Homo sapiens (human) | WASp |
| 2 | A | (2S)-1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(DIMETHYLAMINO)PROPAN-2-OL | non-polymer | 426.1 | 1 | Chemie (WSK) |
Sequence modifications
A: 1 - 69 (UniProt: P42768)
A: 76 - 107 (UniProt: P42768)
A: 76 - 107 (UniProt: P42768)
| PDB | External Database | Details |
|---|---|---|
| Gly 70 | - | SEE REMARK 999 |
| Gly 71 | - | SEE REMARK 999 |
| Ser 72 | - | SEE REMARK 999 |
| Gly 73 | - | SEE REMARK 999 |
| Gly 74 | - | SEE REMARK 999 |
| Ser 75 | - | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 11603.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 426.1 | |
| All* | Total formula weight | 12029.7 |
