1T5Z

Crystal Structure of the Androgen Receptor Ligand Binding Domain (LBD) with DHT and a peptide derived from its physiological coactivator ARA70

1T5Z の概要

• エントリーDOI: 10.2210/pdb1t5z/pdb
• 関連するPDBエントリー: 1T63 1T65
• 分子名称: Androgen receptor, Nuclear receptor coactivator 4, 5-ALPHA-DIHYDROTESTOSTERONE, ... (4 entities in total)
• 機能のキーワード: androgen receptor ligand binding domain ara70 crystal structure coactivators, hormone-growth factor complex, hormone/growth factor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P10275
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31460.90

構造登録者

Estebanez-Perpina, E.,Moore, J.M.R.,Mar, E.,Nguyen, P.,Delgado-Rodrigues, E.,Baxter, J.D.,Webb, P.,Fletterick, R.J.,Guy, R.K. (登録日: 2004-05-05, 公開日: 2005-01-25, 最終更新日: 2024-02-14)

• 主引用文献: Estebanez-Perpina, E.,Moore, J.M.R.,Mar, E.,Delgado-Rodrigues, E.,Nguyen, P.,Baxter, J.D.,Buehrer, B.M.,Webb, P.,Fletterick, R.J.,Guy, R.K.; The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor.; J.Biol.Chem., 280:8060-8068, 2005; PubMed: 15563469; DOI: 10.1074/jbc.M407046200

実験手法

X-RAY DIFFRACTION (2.3 Å)