1T0L
Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP, isocitrate, and calcium(2+)
Summary for 1T0L
Entry DOI | 10.2210/pdb1t0l/pdb |
Related | 1T09 |
Descriptor | Isocitrate dehydrogenase [NADP] cytoplasmic, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | rossmann fold, nadp, isocitrate, calcium, quaternary complex, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: O75874 |
Total number of polymer chains | 4 |
Total formula weight | 190783.32 |
Authors | |
Primary citation | Xu, X.,Zhao, J.,Xu, Z.,Peng, B.,Huang, Q.,Arnold, E.,Ding, J. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity J.Biol.Chem., 279:33946-33957, 2004 Cited by PubMed: 15173171DOI: 10.1074/jbc.M404298200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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