1T0L

Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP, isocitrate, and calcium(2+)

Summary for 1T0L

Entry DOI	10.2210/pdb1t0l/pdb
Related	1T09
Descriptor	Isocitrate dehydrogenase [NADP] cytoplasmic, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	rossmann fold, nadp, isocitrate, calcium, quaternary complex, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: O75874
Total number of polymer chains	4
Total formula weight	190783.32
Authors	Xu, X.,Zhao, J.,Peng, B.,Huang, Q.,Arnold, E.,Ding, J. (deposition date: 2004-04-10, release date: 2004-06-15, Last modification date: 2023-10-25)
Primary citation	Xu, X.,Zhao, J.,Xu, Z.,Peng, B.,Huang, Q.,Arnold, E.,Ding, J. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity J.Biol.Chem., 279:33946-33957, 2004 Cited by PubMed: 15173171 DOI: 10.1074/jbc.M404298200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation