1T0L
Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP, isocitrate, and calcium(2+)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Isocitrate dehydrogenase [NADP] cytoplasmic | polymer | 414 | 46720.2 | 4 | UniProt (O75874) Pfam (PF00180) | Homo sapiens (human) | cytosolic NADP(+)-dependent isocitrate dehydrogenase, Oxalosuccinate decarboxylase, IDH, NADP+-specific ICDH, IDP |
| 2 | E, H, K, N (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 3 | F, I, L, O (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 4 | G, J, M, P (A, B, C, D) | ISOCITRIC ACID | non-polymer | 192.1 | 4 | Chemie (ICT) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 914 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 186880.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3902.4 | |
| All* | Total formula weight | 190783.3 |
