1SIV

THREE-DIMENSIONAL STRUCTURE OF A SIV PROTEASE(SLASH)INHIBITOR COMPLEX. IMPLICATIONS FOR THE DESIGN OF HIV-1 AND HIV-2 PROTEASE INHIBITORS

Summary for 1SIV
Related PRD IDPRD_000320
DescriptorSIV PROTEASE, methyl N-{(4S,5S)-5-[(L-alanyl-L-alanyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-valyl-L-valinate (3 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, acid proteinase, hydrolase/hydrolase inhibitor
Biological sourceSimian immunodeficiency virus
Total number of polymer chains2
Total formula weight22028.61
Authors
Zhao, B.,Abdel-Meguid, S. (deposition date: 1993-08-24, release date: 1994-01-31, Last modification date: 2017-11-29)
Primary citationAbdel-Meguid, S.S.,Culp, J.S.,Debouck, C.,Minnich, M.D.,Winborne, E.,Zhao, B.
Three-dimensional structure of a simian immunodeficiency virus protease/inhibitor complex. Implications for the design of human immunodeficiency virus type 1 and 2 protease inhibitors.
Biochemistry, 32:13054-13060, 1993
PubMed: 8241159
DOI: 110.1021/bi00211a015
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation
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178938

PDB entries from 2021-06-16