1SIV

THREE-DIMENSIONAL STRUCTURE OF A SIV PROTEASE(SLASH)INHIBITOR COMPLEX. IMPLICATIONS FOR THE DESIGN OF HIV-1 AND HIV-2 PROTEASE INHIBITORS

Experimental procedure

Spacegroup name	I 2 2 2
Unit cell lengths	46.300, 101.500, 118.800
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	6.000 - 2.500
R-factor	0.189
Rwork	0.189
RMSD bond length	0.017
RMSD bond angle	3.480
Phasing software	X-PLOR
Refinement software	X-PLOR

Data quality characteristics

	Overall
High resolution limit [Å]	2.500 *
Rmerge	0.068 *
Total number of observations	41170 *
Number of reflections	10018 *
Completeness [%]	99.0 *

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	Vapor diffusion, hanging drop *	5.6 *

Crystallization Reagents in Literatures

ID	crystal ID	solution	reagent name	concentration (unit)	details
1	1	reservoir		25-32 (%sat)
2	1	reservoir	sodium acetate	50 (mM)