1SG1

Crystal Structure of the Receptor-Ligand Complex between Nerve Growth Factor and the Common Neurotrophin Receptor p75

Summary for 1SG1

Entry DOI	10.2210/pdb1sg1/pdb
Descriptor	Beta-nerve growth factor, Tumor necrosis factor receptor superfamily member 16, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	nerve growth factor, ngf, p75, neurotrophin, common neurotrophin receptor, growth factor receptor, receptor-ligand complex, hormone-growth factor-membrane protein complex, hormone/growth factor/membrane protein
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P01138 Membrane; Single-pass type I membrane protein: P07174
Total number of polymer chains	3
Total formula weight	44324.29
Authors	He, X.L.,Garcia, K.C. (deposition date: 2004-02-22, release date: 2004-06-01, Last modification date: 2023-08-23)
Primary citation	He, X.L.,Garcia, K.C. Structure of nerve growth factor complexed with the shared neurotrophin receptor p75 Science, 304:870-875, 2004 Cited by PubMed: 15131306 DOI: 10.1126/science.1095190 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation