1SG1

Crystal Structure of the Receptor-Ligand Complex between Nerve Growth Factor and the Common Neurotrophin Receptor p75

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005102	molecular_function	signaling receptor binding
B	0005102	molecular_function	signaling receptor binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 551

Chain	Residue
A	VAL109
A	CYS110
B	CYS110

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Functional Information from PROSITE/UniProt

site_id	PS00248
Number of Residues	14
Details	NGF_1 Nerve growth factor family signature. GCRGIDskhWnSyC

Chain	Residue	Details
A	GLY67-CYS80

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site_id	PS00652
Number of Residues	41
Details	TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. Cldnvt.Fsdvvsatep.CkpCte.Clglqsmsap..Cvead..DAVC

Chain	Residue	Details
X	CYS39-CYS79
X	CYS79-CYS118
X	CYS121-CYS160

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site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CrCayGYyqdeetghC

Chain	Residue	Details
X	CYS79-CYS94

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"description":"in other chain","evidences":[{"source":"UniProtKB","id":"P01139","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P01139","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	33
Details	Repeat: {"description":"TNFR-Cys 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	41
Details	Repeat: {"description":"TNFR-Cys 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	38
Details	Repeat: {"description":"TNFR-Cys 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	40
Details	Repeat: {"description":"TNFR-Cys 4"}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"20036257","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3BUK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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