1SCN

INACTIVATION OF SUBTILISIN CARLSBERG BY N-(TERT-BUTOXYCARBONYL-ALANYL-PROLYL-PHENYLALANYL)-O-BENZOL HYDROXYLAMINE: FORMATION OF COVALENT ENZYME-INHIBITOR LINKAGE IN THE FORM OF A CARBAMATE DERIVATIVE

1SCN の概要

• エントリーDOI: 10.2210/pdb1scn/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000260
• 分子名称: SUBTILISIN CARLSBERG, N-(tert-butoxycarbonyl)-L-alanyl-N-[(1R)-1-(carboxyamino)-2-phenylethyl]-L-prolinamide, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, serine proteinase, hydrolase/hydrolase inhibitor
• 由来する生物種: Bacillus licheniformis
• 細胞内の位置: Secreted: P00780
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28026.05

構造登録者

Steinmetz, A.C.U.,Demuth, H.-U.,Ringe, D. (登録日: 1994-03-02, 公開日: 1994-08-31, 最終更新日: 2017-11-29)

• 主引用文献: Steinmetz, A.C.,Demuth, H.U.,Ringe, D.; Inactivation of subtilisin Carlsberg by N-((tert-butoxycarbonyl)alanylprolylphenylalanyl)-O-benzolhydroxyl- amine: formation of a covalent enzyme-inhibitor linkage in the form of a carbamate derivative.; Biochemistry, 33:10535-10544, 1994; PubMed: 8068694; DOI: 10.1021/bi00200a040

実験手法

X-RAY DIFFRACTION (1.9 Å)