1SBG
AN ORALLY-BIOAVAILABLE HIV-1 PROTEASE INHIBITOR CONTAINING AN IMIDAZOLE-DERIVED PEPTIDE BOND REPLACEMENT. CRYSTALLOGRAPHIC AND PHARMACOKINETIC ANALYSIS
Summary for 1SBG
Entry DOI | 10.2210/pdb1sbg/pdb |
Descriptor | HIV-1 PROTEASE, (2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE (3 entities in total) |
Functional Keywords | hydrolase(acid protease) |
Biological source | Human immunodeficiency virus type 1 BH10 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 |
Total number of polymer chains | 2 |
Total formula weight | 22196.25 |
Authors | Abdel-Meguid, S.,Zhao, B. (deposition date: 1994-05-24, release date: 1994-10-15, Last modification date: 2024-02-14) |
Primary citation | Abdel-Meguid, S.S.,Metcalf, B.W.,Carr, T.J.,Demarsh, P.,DesJarlais, R.L.,Fisher, S.,Green, D.W.,Ivanoff, L.,Lambert, D.M.,Murthy, K.H.M.,Petteway Jr., S.R.,Pitts, W.J.,Tomaszek Jr., T.A.,Winborne, E.,Zhao, B.,Dreyer, G.B.,Meek, T.D. An orally bioavailable HIV-1 protease inhibitor containing an imidazole-derived peptide bond replacement: crystallographic and pharmacokinetic analysis. Biochemistry, 33:11671-11677, 1994 Cited by PubMed: 7918383DOI: 10.1021/bi00205a001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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