1SBG

AN ORALLY-BIOAVAILABLE HIV-1 PROTEASE INHIBITOR CONTAINING AN IMIDAZOLE-DERIVED PEPTIDE BOND REPLACEMENT. CRYSTALLOGRAPHIC AND PHARMACOKINETIC ANALYSIS

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	HIV-1 PROTEASE	polymer	99	10830.8	2	UniProt (P03366) Pfam (PF00077) In PDB	Human immunodeficiency virus type 1 BH10
2	A	(2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE	non-polymer		534.7	1	Chemie (IM1)
3		water	water		18.0	23	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	21661.6
Non-Polymers*	Number of molecules	1
	Total formula weight	534.7
All*	Total formula weight	22196.3

*Water molecules are not included.