1SBG
AN ORALLY-BIOAVAILABLE HIV-1 PROTEASE INHIBITOR CONTAINING AN IMIDAZOLE-DERIVED PEPTIDE BOND REPLACEMENT. CRYSTALLOGRAPHIC AND PHARMACOKINETIC ANALYSIS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HIV-1 PROTEASE | polymer | 99 | 10830.8 | 2 | UniProt (P03366) Pfam (PF00077) | Human immunodeficiency virus type 1 BH10 | |
| 2 | C (A) | (2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE | non-polymer | 534.7 | 1 | Chemie (IM1) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21661.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 534.7 | |
| All* | Total formula weight | 22196.3 |
