1RHI

HUMAN RHINOVIRUS 3 COAT PROTEIN

Summary for 1RHI

• Entry DOI: 10.2210/pdb1rhi/pdb
• Descriptor: HUMAN RHINOVIRUS 3 COAT PROTEIN, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: human rhinovirus 3, coat protein, icosahedral virus, virus
• Biological source: Human rhinovirus 3; More
• Cellular location: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion: Q82081 Q82081 Q82081 Q82081
• Total number of polymer chains: 4
• Total formula weight: 94347.24

Authors

Zhao, R.,Rossmann, M.G. (deposition date: 1996-06-17, release date: 1997-03-12, Last modification date: 2024-04-03)

Primary citation

Zhao, R.,Pevear, D.C.,Kremer, M.J.,Giranda, V.L.,Kofron, J.A.,Kuhn, R.J.,Rossmann, M.G.
Human rhinovirus 3 at 3.0 A resolution.
Structure, 4:1205-1220, 1996

PubMed Abstract: The over 100 serotypes of human rhinoviruses (HRV) are major causative agents of the common cold in humans. These HRVs can be roughly divided into a major and minor group according to their cellular receptors. They can also be divided into two antiviral groups, A and B, based on their sensitivity to different capsid-binding antiviral compounds. The crystal structures of HRV14 and HRV16, major-receptor group rhinoviruses, as well as HRV1A, a minor-receptor group rhinovirus, were determined previously. Sequence comparisons had shown that HRV14 seemed to be an outlier among rhinoviruses. Furthermore, HRV14 was the only virus with no cellular 'pocket factor' in a hydrophobic pocket which is targeted by many capsid-binding antiviral compounds and is thought to regulate viral stability. HRV3, another major-receptor group virus, was chosen for study because it is one of a subset of serotypes that best represents the drug sensitivity of most rhinovirus serotypes. Both HRV3 and HRV14 belong to antiviral group A, while HRV16 and HRV1A belong to antiviral group B.

PubMed: 8939746
DOI: 10.1016/S0969-2126(96)00128-1

Experimental method

X-RAY DIFFRACTION (3 Å)