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1RA5

Bacterial cytosine deaminase D314A mutant bound to 5-fluoro-4-(S)-hydroxyl-3,4-dihydropyrimidine.

Summary for 1RA5
Entry DOI10.2210/pdb1ra5/pdb
Related1K7O 1R9X 1R9Y 1R9Z 1RA0 1RAK 1RB7
DescriptorCytosine deaminase, FE (III) ION, (4S)-5-FLUORO-4-HYDROXY-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE, ... (5 entities in total)
Functional Keywordscytosine deaminase, alpha-beta barrel, hexamer, conformational change, d314a mutant, hydrolase
Biological sourceEscherichia coli
Total number of polymer chains1
Total formula weight48096.02
Authors
Mahan, S.D.,Ireton, G.C.,Stoddard, B.L.,Black, M.E. (deposition date: 2003-10-31, release date: 2004-10-05, Last modification date: 2024-02-14)
Primary citationMahan, S.D.,Ireton, G.C.,Knoeber, C.,Stoddard, B.L.,Black, M.E.
Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17:625-633, 2004
Cited by
PubMed: 15381761
DOI: 10.1093/protein/gzh074
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.4 Å)
Structure validation

217705

数据于2024-03-27公开中

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