1R9N

Crystal Structure of human dipeptidyl peptidase IV in complex with a decapeptide (tNPY) at 2.3 Ang. Resolution

1R9N の概要

• エントリーDOI: 10.2210/pdb1r9n/pdb
• 関連するPDBエントリー: 1R9M
• 分子名称: Dipeptidyl peptidase IV, Neuropeptide Y, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: alpha/beta hydrolase, eight-bladed beta propeller, serine protease, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 352425.95

構造登録者

Aertgeerts, K.,Ye, S.,Tennant, M.G.,Collins, B.,Rogers, J.,Sang, B.-C.,Skene, R.,Webb, D.R.,Prasad, G.S. (登録日: 2003-10-30, 公開日: 2005-03-29, 最終更新日: 2023-08-23)

• 主引用文献: Aertgeerts, K.,Ye, S.,Tennant, M.G.,Kraus, M.L.,Rogers, J.,Sang, B.-C.,Skene, R.J.,Webb, D.R.,Prasad, G.S.; Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation.; Protein Sci., 13:412-421, 2004; PubMed: 14718659; DOI: 10.1110/ps.03460604

実験手法

X-RAY DIFFRACTION (2.3 Å)