1R8I

Crystal structure of TraC

Summary for 1R8I

Entry DOI	10.2210/pdb1r8i/pdb
Descriptor	TraC (1 entity in total)
Functional Keywords	trac, virb5, helical bundle, structural protein
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	23515.30
Authors	Yeo, H.-J.,Yuan, Q.,Beck, M.R.,Baron, C.,Waksman, G. (deposition date: 2003-10-24, release date: 2004-01-06, Last modification date: 2024-02-14)
Primary citation	Yeo, H.-J.,Yuan, Q.,Beck, M.R.,Baron, C.,Waksman, G. Structural and functional characterization of the VirB5 protein from the type IV secretion system encoded by the conjugative plasmid pKM101 Proc.Natl.Acad.Sci.USA, 100:15947-15952, 2003 Cited by PubMed Abstract: Type IV secretion systems mediate intercellular transfer of macro-molecules via a mechanism ancestrally related to that of bacterial conjugation machineries. TraC of the IncN plasmid pKM101 belongs to the VirB5 family of proteins, an essential component of most type IV secretion systems. Here, we present the structure of TraC. VirB5/TraC is a single domain protein, which consists of a three helix bundle and a loose globular appendage. Structure-based site-directed mutagenesis followed by functional studies indicates that VirB5 proteins participate in protein-protein interactions important for pilus assembly and function. PubMed: 14673074 DOI: 10.1073/pnas.2535211100 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation