1R68
Role of the amino sugar in DNA binding of disaccharide anthracyclines: crystal structure of MAR70/d(CGATCG) complex
Summary for 1R68
| Entry DOI | 10.2210/pdb1r68/pdb |
| Descriptor | 5'-D(*CP*GP*AP*TP*CP*G)-3', 4'-EPI-4'-(2-DEOXYFUCOSE)DAUNOMYCIN (3 entities in total) |
| Functional Keywords | right handed dna, double helix, drug-dna complex, dna |
| Total number of polymer chains | 1 |
| Total formula weight | 2466.88 |
| Authors | Temperini, C.,Cirilli, M.,Aschi, M.,Ughetto, G. (deposition date: 2003-10-15, release date: 2005-02-22, Last modification date: 2024-02-14) |
| Primary citation | Temperini, C.,Cirilli, M.,Aschi, M.,Ughetto, G. Role of the amino sugar in DNA binding of disaccharide anthracyclines: crystal structure of the complex MAR70/d(CGATCG). BIOORG.MED.CHEM., 13:1673-1679, 2005 Cited by PubMed Abstract: Disaccharide anthracyclines analogues have been shown to exhibit different antitumour activity as compared with parents compounds doxorubicin and daunomycin. Here we report the crystal structure of the disaccharide analog MAR70 complexed with the DNA hexamer d(CGATCG). The structure has been solved at 1.54A resolution and is similar to previous crystallized anthracycline-DNA complexes with both sugar rings of the disaccharide chain lying in the DNA minor groove. Comparison with the structure of MEN10755 another disaccharide anthracycline co-crystallized with the same DNA hexamer suggests a correlation between the position of the amino sugar on the disaccharide chain and the conformation of this moiety when binding to DNA. This is discussed with respect to the influence on drug activity and on the possible interaction with other cellular targets. PubMed: 15698785DOI: 10.1016/j.bmc.2004.12.007 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
Download full validation report
