1R64

The 2.2 A crystal structure of Kex2 protease in complex with Ac-Arg-Glu-Lys-boroArg peptidyl boronic acid inhibitor

Summary for 1R64

Entry DOI	10.2210/pdb1r64/pdb
Related PRD ID	PRD_000420
Descriptor	Kexin, Ac-Arg-Glu-Lys-boroArg peptide inhibitor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	kex2, kexin, protease, protein convertase, prohormone processing, proprotein convertase, subtilisin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Saccharomyces cerevisiae (baker's yeast) More
Cellular location	Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein: P13134
Total number of polymer chains	4
Total formula weight	108707.82
Authors	Holyoak, T.,Kettner, C.A.,Petsko, G.A.,Fuller, R.S.,Ringe, D. (deposition date: 2003-10-14, release date: 2004-03-09, Last modification date: 2023-11-15)
Primary citation	Holyoak, T.,Kettner, C.A.,Petsko, G.A.,Fuller, R.S.,Ringe, D. Structural Basis for Differences in Substrate Selectivity in Kex2 and Furin Protein Convertases Biochemistry, 43:2412-2421, 2004 Cited by PubMed: 14992578 DOI: 10.1021/bi035849h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation