1R49

Human topoisomerase I (Topo70) double mutant K532R/Y723F

Summary for 1R49

• Entry DOI: 10.2210/pdb1r49/pdb
• Related: 1A36 1EJ9 1K4S 1K4T 1LPQ 1TMC
• Descriptor: 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(P*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I, ... (4 entities in total)
• Functional Keywords: protein, dna, topoisomerase i, isomerase-dna complex, isomerase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleolus: P11387
• Total number of polymer chains: 3
• Total formula weight: 83675.90

Authors

Interthal, H.,Quigley, P.M.,Hol, W.G.,Champoux, J.J. (deposition date: 2003-10-03, release date: 2003-12-16, Last modification date: 2024-02-14)

• Primary citation: Interthal, H.,Quigley, P.M.,Hol, W.G.,Champoux, J.J.; The role of lysine 532 in the catalytic mechanism of human topoisomerase I.; J.Biol.Chem., 279:2984-2992, 2004; PubMed: 14594810; DOI: 10.1074/jbc.M309959200

Experimental method

X-RAY DIFFRACTION (3.13 Å)