1R0A

Crystal structure of HIV-1 reverse transcriptase covalently tethered to DNA template-primer solved to 2.8 angstroms

1R0A の概要

• エントリーDOI: 10.2210/pdb1r0a/pdb
• 関連するPDBエントリー: 1HYS 1N5Y 1N6Q
• 分子名称: 5'-D(*A*TP*GP*CP*AP*TP*CP*GP*GP*CP*GP*CP*TP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*GP*GP*T)-3', 5'-D(*C*CP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*AP*GP*CP*GP*CP*CP*GP*(2DA))-3', Reverse transcriptase, ... (10 entities in total)
• 機能のキーワード: hiv-1, transferase, immune system, dna, transferase-immune system-dna complex, transferase/immune system/dna
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 176881.90

構造登録者

Tuske, S.,Ding, J.,Arnold, E. (登録日: 2003-09-19, 公開日: 2004-08-03, 最終更新日: 2021-10-27)

• 主引用文献: Peletskaya, E.N.,Kogon, A.A.,Tuske, S.,Arnold, E.,Hughes, S.H.; Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA.; J.Virol., 78:3387-3397, 2004; PubMed: 15016861; DOI: 10.1128/JVI.78.7.3387-3397.2004

実験手法

X-RAY DIFFRACTION (2.8 Å)