1QZY

Human Methionine Aminopeptidase in complex with bengamide inhibitor LAF153 and cobalt

1QZY の概要

• エントリーDOI: 10.2210/pdb1qzy/pdb
• 分子名称: Methionine aminopeptidase 2, COBALT (II) ION, (E)-(2R,3R,4S,5R)-3,4,5-TRIHYDROXY-2-METHOXY-8,8-DIMETHYL-NON-6-ENOIC ACID ((3S,6R)-6-HYDROXY-2-OXO-AZEPAN-3-YL)-AMIDE, ... (5 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53566.00

構造登録者

Eck, M.J.,Song, H.K.,Morollo, A. (登録日: 2003-09-18, 公開日: 2003-11-25, 最終更新日: 2011-07-13)

• 主引用文献: Towbin, H.,Bair, K.W.,DeCaprio, J.A.,Eck, M.J.,Kim, S.,Kinder, F.R.,Morollo, A.,Mueller, D.R.,Schindler, P.,Song, H.K.,van Oostrum, J.,Versace, R.W.,Voshol, H.,Wood, J.,Zabludoff, S.,Phillips, P.E.; Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors.; J.Biol.Chem., 278:52964-52971, 2003; PubMed: 14534293; DOI: 10.1074/jbc.M309039200

実験手法

X-RAY DIFFRACTION (1.6 Å)