1QX4

Structrue of S127P mutant of cytochrome b5 reductase

Summary for 1QX4

Entry DOI	10.2210/pdb1qx4/pdb
Related	1I7P 1IB0
Descriptor	NADH-cytochrome b5 reductase, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total)
Functional Keywords	methemoglobinemia, flavin flexibility, oxidoreductase
Biological source	Rattus norvegicus (Norway rat)
Cellular location	Isoform 1: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Isoform 3: Cytoplasm: P20070
Total number of polymer chains	2
Total formula weight	64221.53
Authors	Bewley, M.C.,Davis, C.A.,Marohnic, C.C.,Taormina, D.,Barber, M.J. (deposition date: 2003-09-04, release date: 2004-09-14, Last modification date: 2023-08-23)
Primary citation	Bewley, M.C.,Davis, C.A.,Marohnic, C.C.,Taormina, D.,Barber, M.J. The structure of the S127P mutant of cytochrome b5 reductase that causes methemoglobinemia shows the AMP moiety of the flavin occupying the substrate binding site Biochemistry, 42:13145-13151, 2003 Cited by PubMed: 14609324 DOI: 10.1021/bi034915c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation