1QPV

YEAST COFILIN

Summary for 1QPV

• Entry DOI: 10.2210/pdb1qpv/pdb
• Related: 1CFY 1COF
• Descriptor: YEAST COFILIN (1 entity in total)
• Functional Keywords: three layers:alpha/mixed beta/alpha ; cofilin fold; actin-binding protein, actin-binding protein
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Cellular location: Cytoplasm: Q03048
• Total number of polymer chains: 1
• Total formula weight: 15919.74

Authors

Fedorov, A.A.,Lappalainen, P.,Fedorov, E.V.,Drubin, D.G.,Almo, S.C. (deposition date: 1999-05-29, release date: 1999-06-08, Last modification date: 2023-08-16)

Primary citation

Fedorov, A.A.,Lappalainen, P.,Fedorov, E.V.,Drubin, D.G.,Almo, S.C.
Structure determination of yeast cofilin.
Nat.Struct.Biol., 4:366-369, 1997

PubMed Abstract: Cofilin, a ubiquitous 15,000 M(r) protein, plays a central role in regulating cytoskeletal dynamics. Cofilin binds to actin monomers and filaments, and has a pH-dependent actin severing activity. The structure will allow for a detailed analysis of cofilin function.

PubMed: 9145106
DOI: 10.1038/nsb0597-366

Experimental method

X-RAY DIFFRACTION (3 Å)